%0 Journal Article
%T Left Ventricular Mass in Dialysis Patients, Determinants and Relation with Outcome. Results from the COnvective TRansport STudy (CONTRAST)
%A Ira M. Mostovaya
%A Michiel L. Bots
%A Marinus A. van den Dorpel
%A Roel Goldschmeding
%A Claire H. den Hoedt
%A Otto Kamp
%A Ren谷e Levesque
%A Albert H. A. Mazairac
%A E. Lars Penne
%A Dorine W. Swinkels
%A Neelke C. van der Weerd
%A Piet M. ter Wee
%A Menso J. Nub谷
%A Peter J. Blankestijn
%A Muriel P. C. Grooteman
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0084587
%X Background and Objectives Left ventricular mass (LVM) is known to be related to overall and cardiovascular mortality in end stage kidney disease (ESKD) patients. The aims of the present study are 1) to determine whether LVM is associated with mortality and various cardiovascular events and 2) to identify determinants of LVM including biomarkers of inflammation and fibrosis. Design, Setting, Participants, & Measurements Analysis was performed with data of 327 ESKD patients, a subset from the CONvective TRAnsport STudy (CONTRAST). Echocardiography was performed at baseline. Cox regression analysis was used to assess the relation of LVM tertiles with clinical events. Multivariable linear regression models were used to identify factors associated with LVM. Results Median age was 65 (IQR: 54每73) years, 203 (61%) were male and median LVM was 227 (IQR: 183每279) grams. The risk of all-cause mortality (hazard ratio (HR) = 1.73, 95% CI: 1.11每2.99), cardiovascular death (HR = 3.66, 95% CI: 1.35每10.05) and sudden death (HR = 13.06; 95% CI: 6.60每107) was increased in the highest tertile (>260grams) of LVM. In the multivariable analysis positive relations with LVM were found for male gender (B = 38.8㊣10.3), residual renal function (B = 17.9㊣8.0), phosphate binder therapy (B = 16.9㊣8.5), and an inverse relation for a previous kidney transplantation (B = ˋ41.1㊣7.6) and albumin (B = ˋ2.9㊣1.1). Interleukin-6 (Il-6), high-sensitivity C-reactive protein (hsCRP), hepcidin-25 and connective tissue growth factor (CTGF) were not related to LVM. Conclusion We confirm the relation between a high LVM and outcome and expand the evidence for increased risk of sudden death. No relationship was found between LVM and markers of inflammation and fibrosis. Trial Registration Controlled-Trials.com ISRCTN38365125
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084587