%0 Journal Article
%T Clinical Evaluation of an Arterial-Spin-Labeling Product Sequence in Steno-Occlusive Disease of the Brain
%A Matthias A. Mutke
%A Vince I. Madai
%A Federico C. von Samson-Himmelstjerna
%A Olivier Zaro Weber
%A Gajanan S. Revankar
%A Steve Z. Martin
%A Katharina L. Stengl
%A Miriam Bauer
%A Stefan Hetzer
%A Matthias G¨šnther
%A Jan Sobesky
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0087143
%X Introduction In brain perfusion imaging, arterial spin labeling (ASL) is a noninvasive alternative to dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI). For clinical imaging, only product sequences can be used. We therefore analyzed the performance of a product sequence (PICORE-PASL) included in an MRI software-package compared with DSC-MRI in patients with steno-occlusion of the MCA or ICA >70%. Methods Images were acquired on a 3T MRI system and qualitatively analyzed by 3 raters. For a quantitative analysis, cortical ROIs were placed in co-registered ASL and DSC images. Pooled data for ASL-cerebral blood flow (CBF) and DSC-CBF were analyzed by SpearmanĄ¯s correlation and the Bland-Altman (BA)-plot. Results In 28 patients, 11 ASL studies were uninterpretable due to patient motion. Of the remaining patients, 71% showed signs of delayed tracer arrival. A weak correlation for DSC-relCBF vs ASL-relCBF (r = 0.24) and a large spread of values in the BA-plot owing to unreliable CBF-measurement was found. Conclusion The PICORE ASL product sequence is sensitive for estimation of delayed tracer arrival, but cannot be recommended to measure CBF in steno-occlusive disease. ASL-sequences that are less sensitive to patient motion and correcting for delayed blood flow should be available in the clinical setting.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087143