%0 Journal Article
%T Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients
%A Georgios Grammatikos
%A Christian Lange
%A Simone Susser
%A Susanne Schwendy
%A Nektarios Dikopoulos
%A Peter Buggisch
%A Jens Encke
%A Gerlinde Teuber
%A Tobias Goeser
%A Robert Thimme
%A Hartwig Klinker
%A Wulf O. Boecher
%A Ewert Schulte-Frohlinde
%A Marissa Penna-Martinez
%A Klaus Badenhoop
%A Stefan Zeuzem
%A Thomas Berg
%A Christoph Sarrazin
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0087974
%X Background Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-汐 and ribavirin for 24每72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002每1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975每0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000每1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073每2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271每4.695, P = 0.007) constituted the strongest predictors of treatment response. Conclusions While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0087974