%0 Journal Article
%T Incidence and Metastasis of Cutaneous Malignant Melanoma with Respect to ABO Blood Groups: A Case-Controlled Study in Northeast of China
%A Liang Chang
%A Junrui Pei
%A Chenlong Li
%A Ping Zhang
%A Dan Zhou
%A Wenzhong Du
%A Xing Liu
%A Chuanlu Jiang
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0088096
%X Background ABO blood groups have been suggested to contribute to the development of certain tumors; however, the associations between ABO blood groups and the incidence and metastases of cutaneous malignant melanomas have not been fully evaluated in Chinese populations. Thus, we investigated these associations with a case-controlled study in northeast of China. Methods A total of 482 patients with cutaneous malignant melanoma and 3,068 healthy- controls were enrolled for the study between 2001 and 2012 at The Tumor Hospital of Harbin Medical University. A multivariate logistic model was used to evaluate adjusted odds ratios (ORs) and 95% confidence intervals (CI) for the incidence and metastases of cutaneous malignant melanoma. Results Blood type A individuals had higher tumor incidence and metastasis compared to those with blood type O (OR = 1.575; 95% CI = 1.208¨C2.053, p = 0.001; OR = 2.004; 95% CI = 1.032¨C3.889, p = 0.040), after adjusting for age, gender, smoking status and alcohol consumption. Conclusions Blood type A was associated with higher incidence and metastasis of cutaneous malignant melanoma but future studies are needed to examine the mechanisms linking cutaneous malignant melanoma to ABO blood types.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088096