%0 Journal Article
%T Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2£¿ Production
%A Sara Franceschelli
%A Mirko Pesce
%A Alessio Ferrone
%A Maria Anna De Lutiis
%A Antonia Patruno
%A Alfredo Grilli
%A Mario Felaco
%A Lorenza Speranza
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0088359
%X Recently, astaxanthin (ASTA) studies have focused on several biological functions such as radical scavenging, singlet oxygen quenching, anti-carcinogenesis, anti-diabetic, anti-obesity, anti-inflammatory, anti-melanogenesis, and immune enhancement activities. In this study, we investigated the potential role protective of ASTA, an antioxidant marine carotenoid, in restoring physiological conditions in U937 cells stimulated with LPS (10 ¦Ìg/ml). Our results show that pre-treatment with ASTA (10 ¦ÌM) for 1 h attenuates the LPS-induced toxicity and ROS production. The beneficial effect of ASTA is associated with a reduction intracellular O2£¿ production by restoring the antioxidant network activity of superoxide dismutase (SOD) and catalase (CAT), which influence HO-1 expression and activity by inhibiting nuclear translocation of Nrf2. We accordingly hypothesize that ASTA has therapeutic properties protecting U937 cells from LPS-induced inflammatory and oxidative stress.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088359