%0 Journal Article
%T Association of a TNIP1 Polymorphism with Vogt-Koyanagi-Harada Syndrome but Not with Ocular Behcet¡¯s Disease in Han Chinese
%A Yanyun Shi
%A Yading Jia
%A Shengping Hou
%A Jing Fang
%A Yan Zhou
%A Aize Kijlstra
%A Peizeng Yang
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0095573
%X Objectives The aim of the study was to investigate the association of TNF¦Á-induced protein 3 interacting with protein 1 (TNIP1) gene polymorphisms with Vogt¨CKoyanagi¨CHarada (VKH) syndrome and Behcet¡¯s disease (BD) in a Han Chinese population. Methods A total of 656 BD patients, 961 VKH syndrome patients and 1534 healthy controls were included in this two-stage case control study. Seven SNPs, including rs17728338, rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, belonging to TNIP1 were genotyped and analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The data were analyzed by using the ¦Ö2 or Fisher's exact test and corrected for multiple comparisons by the Bonferroni method. Results A significantly increased frequency of the GG genotype and a decreased frequency of the AG genotype of rs17728338 were found in VKH patients (Pc = 0.038 OR = 1.934, 95% CI = 1.438~2.601). No significant difference was noted in allele or genotype frequencies of rs7708392, rs10036748, rs3762999, rs999556, rs4958881 and rs3792783, between VKH patients and healthy controls (Pc>0.05). No significant difference was noted in allele or genotype frequencies of the tested 7 SNPs between BD patients and healthy controls. Analysis of extraocular clinical findings, did not reveal an association of the TNIP1 gene polymorphisms with BD or VKH syndrome subgroups. Conclusion A TNIP1 polymorphism may be a risk factor for VKH syndrome in Han Chinese.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095573