%0 Journal Article %T Tea Consumption and Risk of Head and Neck Cancer %A Cheng-Chih Huang %A Wei-Ting Lee %A Sen-Tien Tsai %A Chun-Yen Ou %A Hung-I Lo %A Tung-Yiu Wong %A Sheen-Yie Fang %A Ken-Chung Chen %A Jehn-Shyun Huang %A Jiunn-Liang Wu %A Chia-Jui Yen %A Wei-Ting Hsueh %A Yuan-Hua Wu %A Ming-Wei Yang %A Forn-Chia Lin %A Jang-Yang Chang %A Kwang-Yu Chang %A Shang-Yin Wu %A Jenn-Ren Hsiao %A Chen-Lin Lin %A Yi-Hui Wang %A Ya-Ling Weng %A Han-Chien Yang %A Jeffrey S. Chang %J PLOS ONE %D 2014 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0096507 %X Background The current study evaluated the association between tea consumption and head and neck cancer (HNC) in Taiwan, where tea is a major agricultural product and a popular beverage. Methods Interviews regarding tea consumption (frequency, duration, and types) were conducted with 396 HNC cases and 413 controls. Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence interval (CI) of HNC risk associated with tea drinking, adjusted for sex, age, education, cigarette smoking, betel quid chewing, and alcohol drinking. Results A reduced HNC risk associated with tea drinking (OR for every cup per day = 0.96, 95% CI: 0.93¨C0.99; OR for ¨R5 cups per day = 0.60, 95% CI: 0.39¨C0.94) was observed. The association was especially significant for pharyngeal cancer (OR for every cup per day = 0.93, 95% CI: 0.88¨C0.98; OR for ¨R5 cups per day = 0.32, 95% CI: 0.16¨C0.66). A significant inverse association between HNC and tea consumption was observed particularly for green tea. Conclusions This study suggests that tea drinking may reduce the risk of HNC. The anticancer property of tea, if proven, may offer a natural chemopreventive measure to reduce the occurrence of HNC. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096507