%0 Journal Article
%T The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival Signaling
%A Sung-Gyoo Park
%A Meixiao Long
%A Jung-Ah Kang
%A Woo-Seok Kim
%A Cho-Rong Lee
%A Sin-Hyeog Im
%A Ian Strickland
%A Jan Schulze-Luehrmann
%A Matthew S. Hayden
%A Sankar Ghosh
%J PLOS ONE
%D 2013
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0055378
%X Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-¦ĘB activation. PDK1 is also an important regulator of T cell development, mediating pre-TCR induced proliferation signals. However, the role of PDK1 in B cell antigen receptor (BCR) signaling and B cell development remains largely unknown. In this study we provide genetic evidence supporting the role of PDK1 in B cell survival. We found PDK1 is required for BCR mediated survival in resting B cells, likely through regulation of Foxo activation. PDK1-dependent signaling to NF-¦ĘB is not crucial to resting B cell viability. However, PDK1 is necessary for triggering NF-¦ĘB during B cell activation and is required for activated B cell survival. Together these studies demonstrate that PDK1 is essential for BCR-induced signal transduction to Foxo and NF-¦ĘB and is indispensable for both resting and activated B cell survival.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055378