%0 Journal Article
%T Potentially Functional Polymorphism in IL-23 Receptor and Risk of Acute Myeloid Leukemia in a Chinese Population
%A Xifeng Qian
%A Songyu Cao
%A Guohua Yang
%A Yun Pan
%A Chenyu Yin
%A Xiang Chen
%A Ying Zhu
%A Yun Zhuang
%A Yunfeng Shen
%A Zhibin Hu
%J PLOS ONE
%D 2013
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0055473
%X The interleukin-23 (IL-23) and its receptor (IL-23R) mediate the direct antitumor activities in human hematologic malignancies including pediatric acute leukemia. Two potentially functional genetic variants (IL-23R rs1884444 T>G and rs6682925 T>C) have been found to contribute to solid cancer susceptibility. In this study, we conducted a case-control study including 545 acute myeloid leukemia (AML) patients and 1,146 cancer-free controls in a Chinese population to assess the association between these two SNPs and the risk of AML. We found that IL-23R rs1884444 TG/GG and rs6682925 TC/CC variant genotypes were associated with significantly increased risk of AML [rs1884444: adjusted odds ratio (OR) = 1.28, 95% confidence interval (CI) = 1.01¨C1.62; rs6682925: adjusted OR = 1.30, 95%CI = 1.01¨C1.67], compared to their corresponding wild-type homozygotes, respectively. These findings indicated that genetic variants in IL-23R may contribute to AML risk in our Chinese population.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055473