%0 Journal Article
%T SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1
%A Pan Chen
%A Xiaofang Guo
%A Houde Zhou
%A Wenling Zhang
%A Zhaoyang Zeng
%A Qianjin Liao
%A Xiayu Li
%A Bo Xiang
%A Jianbo Yang
%A Jian Ma
%A Ming Zhou
%A Shuping Peng
%A Juanjuan Xiang
%A Xiaoling Li
%A Colvin Wanshura LE
%A Wei Xiong
%A James B. McCarthy
%A Guiyuan Li
%J PLOS ONE
%D 2013
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0056929
%X Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056929