%0 Journal Article
%T A Novel Electrocardiographic Index for the Diagnosis of Diastolic Dysfunction
%A Mehdi Namdar
%A Patric Biaggi
%A Barbara Stˋhli
%A Bernhard B邦tler
%A Rub谷n Casado-Arroyo
%A Danilo Ricciardi
%A Mois谷s Rodr赤guez-Maˋero
%A Jan Steffel
%A David H邦rlimann
%A Christian Schmied
%A Carlo de Asmundis
%A Gian-Battista Chierchia
%A Andrea Sarkozy
%A Thomas F. L邦scher
%A Rolf Jenni
%A Firat Duru
%A Walter J. Paulus
%A Pedro Brugada
%J PLOS ONE
%D 2013
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0079152
%X Background Although the assessment of diastolic dysfunction (DD) is an integral part of routine cardiologic examinations, little is known about associated electrocardiographic (ECG) changes. Our aim was to investigate a potential role of ECG indices for the recognition of patients with DD. Methods and Results ECG parameters correlating with echocardiographic findings of DD were retrospectively assessed in a derivation group of 172 individuals (83 controls with normal diastolic function, 89 patients with DD) and their diagnostic performance was tested in a validation group of 50 controls and 50 patients. The patient group with a DD Grade 1 and 2 showed longer QTc (422㊣24ms and 434㊣32ms vs. 409㊣25ms, p<0.0005) and shorter Tend每P and Tend每Q intervals, reflecting the electrical and mechanical diastole (240㊣78ms and 276㊣108ms vs. 373㊣110ms, p<0.0001; 409㊣85ms and 447㊣115ms vs. 526㊣119ms, p<0.0001). The PQ每interval was significantly longer in the patient group (169㊣28ms and 171㊣38ms vs. 153㊣22ms, p<0.005). After adjusting for possible confounders, a novel index (Tend每P/[PQxAge]) showed a high performance for the recognition of DD, stayed robust in the validation group (sensitivity 82%, specificity 93%, positive predictive value 93%, negative predictive value 82%, accuracy 88%) and proved a substantial added value when combined with the indexed left atrial volume (LAESVI, sensitivity 90%, specificity 92%, positive predictive value 95%, negative predictive value 86%, accuracy 91%). Conclusions A novel electrocardiographic index Tend每P/(PQxAge) demonstrates a high diagnostic accuracy for the diagnosis of DD and yields a substantial added value when combined with the LAESVI.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0079152