%0 Journal Article
%T The Inter-Arm Diastolic Blood Pressure Difference Induced by One Arm Ischemia: A New Approach to Assess Vascular Endothelia Function
%A Weitong Hu
%A Juxiang Li
%A Hai Su
%A Jiwei Wang
%A Jinsong Xu
%A Yanna Liu
%A Ming Huang
%A Xiaoshu Cheng
%J PLOS ONE
%D 2014
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0084765
%X Objectives To evaluate whether inter-arm diastolic blood pressure difference (DBPl-r) induced by one arm ischemia correlates with flow-mediated dilatation (FMD). Methods Bilateral arm BPs were simultaneously measured with two automatic devices and right brachial artery diameter (D) was measured by ultrasound technique in 108 subjects (56 hypertensives and 52 normotensives). Following baseline diameter (D0) and BP measurement, right brachial artery was occluded for 5 minutes. The diameter was measured at 1, 1.5 and 2 min, and bilateral BPs measured at 3, 4 and 5 min after occlusion release. Their averages were recorded as post-D and post-BP, respectively. The difference between post-D and D0 (¦¤D) was calculated as the percentage increase of artery diameter (¦¤D/D0). The BP difference between left and right arms was calculated as BPl-r, and the difference of post- BPl-r and baseline BPl-r was recorded as the net change of BPl-r (¦¤BPl-r). Results At baseline, bilateral SBPs and DBPs were similar. Right arm ischemia induced significant DBP decline only in the right arm (68.8¡À12.7 vs 72.6¡À12.0 mmHg, P<0.05), which led to an increase of ¦¤DBPl-r (4.00¡À3.75 vs 0.78¡À4.47 mmHg, P<0.05). A positive correlation was seen between ¦¤D/D0 and ¦¤DBPl-r (r = 0.744, p<0.001). Furthermore, the correlation between age and ¦¤DBPl-r (r = £¿0.358, P<0.01) was similar to that between age and D/D0 (r = £¿0.398, P<0.01). Meanwhile, both ¦¤DBPl-r and ¦¤D/D0 were significantly lower in hypertensive patients than in normotensive patients. Conclusion The inter-arm DBP difference induced by one arm ischemia may be a potential index for clinical evaluation of vascular endothelial function.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084765