%0 Journal Article
%T A Low-Power CMOS Analog Front-End IC with Adjustable On-Chip Filters for Biosensors
%A Donald Y. C. Lie
%A Vighnesh Das
%A Weibo Hu
%A Yenting Liu
%A Tam Nguyen
%J Open Journal of Applied Biosensor
%P 104-111
%@ 2168-5398
%D 2013
%I Scientific Research Publishing
%R 10.4236/ojab.2013.24014
%X This paper presents a low-power CMOS analog front-end (AFE) IC designed with a selectable on-chip dual AC/DC- coupled paths for bio-sensor applications. The DC-coupled path can be selected to sense a biosignal with useful DC information, and the AC-coupled path can be selected for sensing the AC content of the biosignal by attenuating the unwanted DC component. The AFE IC includes a DC-coupled instrumentation amplifier (INA), two variable-gain 1<sup>st</sup>-order low pass filters (LPF) with tunable cut-off frequencies, a fixed gain 2<sup>nd</sup>-order Sallen-Key high-pass filter (HPF) with tunable cut-off frequencies, a buffer and an 8-bit differential successive approximation register (SAR) ADC. The entire AFE channel is designed and fabricated in a proprietary 0.35-¦Ìm CMOS technology. Excluding an external buffer needed to properly drive the ADC, the measured AFE IC consumes only 2.37 ¦ÌA/channel with an input referred noise of ~40 ¦ÌV<sub>rms </sub>in [1 Hz, 1 kHz], and successfully displays proper ECG (electrocardiogram) and electrogram (EGM) waveforms for QRS peaks detection. We expect that the low-power dual-path design of this AFE IC can enable it to periodically record both the AC and the DC signals for proper sensing and calibration for various bio-sensing applications.
%K Low-Power CMOS
%K Bio-Sensor Applications
%K DC-Coupled
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=39761