%0 Journal Article %T Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions %A Yueqin Cai %A Gonghua Song %A Zhongyuan Wu %A Jiawei Zhang %J Green and Sustainable Chemistry %P 1-5 %@ 2160-696X %D 2013 %I Scientific Research Publishing %R 10.4236/gsc.2013.34A001 %X

Water-soluble ionic liquid-supported diols have been used as phosphine-free ligands in Suzuki couplings of aryl idides/bromides/chlorides under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-mehyl) propane-1,3-diol hexafluorophosphate (4) in combination with palladium (II) salts gave the most significant catalyst. Suzuki couplings of aryl iodides/bromides occurred efficiently at room temperature in water/acetonitrile. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. The catalyst PdCl2-4 was recycled five times in Suzuki couplings in water before catalyst activity began to significantly drop. The average yield of five cycles was >95% per cycle.

%K Suzuki Reaction %K Ionic Liquid-Supported Diols %K Phosphine-Free Ligands %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=39883