%0 Journal Article %T Clinical, aetiological and evolutive aspects of West syndrome in Yaoundé (Cameroon) %A S¨¦raphin Nguefack %A Boniface Moifo %A Andr¨¦as Chiabi %A Antoine Ledoux Defo %A Evelyn Mah %A Florence Fru %A Paul C¨¦dric Mbonda %A Pierre Fernand Tchokoteu %A Elie Mbonda %J Open Journal of Pediatrics %P 306-310 %@ 2160-8776 %D 2013 %I Scientific Research Publishing %R 10.4236/ojped.2013.34055 %X

Background: West syndrome (WS) is an epileptic syndrome of the infant occurring between the 3rd and 12th months of life and characterized by the triad: infantile spasms in flexion, extension or mixed; global developmental delay; and hypsarrythmia on the electroencephalogram (EEG). Its incidence varies between 2.9 and 4.5 per 10,000 live births. West syndrome is caused by a brain dysfunction whose origins can be prenatal, neonatal and postnatal. Sometimes the aetiology is genetic or unknown. Purpose: To determine the main clinical, aetiological and major evolutive aspects of West syndrome in child neurology unit in a university-affiliated hospital in Yaound¨¦. Materials and Methods: It was a retrospective descriptive study conducted from September 2011 to January 2012 inthe child neurology unit of the Yaound¨¦ gynaeco-obstetric and paediatric hospital. The medical records of 68 children followed for West syndrome (WS) in the service during the period from February 2008 to January 2012 (48 months) were used. All infants of 1- to 16-month-old with the diagnosis of WS were included. The diagnosis of WS was based on clinical evidence of spasm in flexion and/or in extension with global development delay, and EEG evidence of hypsarythmia or focal/multifocal epileptic abnormalities when hypsarythmia is absent. For each included infant, relevant medical history and complete physical examination were performed. The following data were collected and reported on a standardized questionnaire: prenatal, perinatal and postnatal past histories, age at onset of spasms, age at diagnosis, semiology of spasms, psychomotor development, the EEG and CT aspects and the evolutive modes of WS under treatment. Psychomotor development was assessed using theDenverdevelopmental screening test (DDST) which assesses the mental age compared to %K West Syndrome %K Epilepsy %K Aetiology %K Evolution %K Cameroon %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=40103