%0 Journal Article
%T One-Step Preparation of Poly-Lactic-Co-Glycolic-Acid Microparticles to Prevent the Initial Burst Release of Encapsulated Water-Soluble Proteins
%A Hiroyuki Takabe
%A Moriyuki Ohkuma
%A Yasunori Iwao
%A Shuji Noguchi
%A Shigeru Itai
%J Pharmacology & Pharmacy
%P 578-583
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.48083
%X <span><span style=\"font-family:Verdana;\">An initial burst is often observed during the release of active pharmaceutical ingredients (APIs) from poly-lactic-coglycolic-acid (PLGA) microparticles (MPs) which have been prepared by the emulsion-solvent evaporation method. Herein, we describe the development of a simple one-step coating method that suppresses the initial burst release process. This new method involves coating the PLGA-MPs with PLGA, with the coating process being performed through the phase separation of PLGA on the surface of PLGA-MPs using the emulsion-solvent evaporation method. Bovine serum albumin (BSA) was encapsulated in the PLGA-MPs as a model API. The coated MPs were spherical in shape with no pores on their smooth surface, whereas the non-coated PLGA-MPs had porous surfaces. An </span><i><span style=\"font-family:Verdana;\">in vitro</span></i><span style=\"font-family:Verdana;\"> release study showed that the residual levels of BSA in the coated and non-coated PLGA-MPs after 1 h were about 99</span></span><span style=\"font-family:Verdana;\">%</span><span style=\"font-family:Verdana;\"> and 16% of the original loads, respectively. The one-step coating method therefore represents a useful method for preparing PLGA-MPs that do not give an initial burst release of proteinaceous APIs.</span><span></span> 
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%K Poly-Lactic-Co-Glycolic-Acid
%K Microparticle
%K Suppression of Initial Burst Release
%K Coating
%K Bovine Serum Albumin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=39270