%0 Journal Article
%T Comparison on Efficacy and Safety of Three Inpatient Insulin Regimens for Management of Non-Critical Patients with Type 2 Diabetes
%A Eman Said
%A Samar Farid
%A Nirmeen Sabry
%A May Fawzi
%J Pharmacology & Pharmacy
%P 556-565
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.47080
%X <span style=\"font-family:Verdana;color:black;font-size:10pt;\">Background: </span><span style=\"font-family:'Times New Roman','serif';color:black;font-size:10pt;\"><span style=\"font-family:Verdana;\">Hyperglycemia in hospitalized patients is associated with poor clinical outcomes. Scheduled Subcutaneous Insulin therapy has been recommended for better glycemic control. </span><span style=\"font-family:Verdana;\">Aims: </span><span style=\"font-family:Verdana;\">To compare efficacy and safety of traditional sliding scale insulin (SSI) versus modified 70/30 insulin versus basal plus supplemental scale (SS) insulin regimens for glycemic control of inpatients with diabetes. </span><span style=\"font-family:Verdana;\">Methods: </span><span style=\"font-family:Verdana;\">In a prospective trial, 62 patients with diabetes were randomized to receive either hospital SSI (N = 22), or twice daily 70/30 insulin plus supplemental lunchtime insulin for BG ¡Ý 150 mg/dL (N = 21) or once every night glargine plus prandial glulisine for BG ¡Ý 150 mg/dL (N = 19). 70/30 insulin and glargine were started respectively at 0.4 and 0.2 U/kg/day for BG ¡Ü 200 mg/dL or 0.5 and 0.3 U/kg/day for BG above 200 mg/dL. </span><span style=\"font-family:Verdana;\">Results: </span><span style=\"font-family:Verdana;\">Starting at BG level of 204 ¡À 68, 200 ¡À 50 and 241 ¡À 94 mg/dL in SSI, 70/30 insulin and glargine/glulisine groups respectively, (F(2,35.47) = 1.467, p = 0.244, Welch test), mean daily BG after first day of hospitalization was statistically significant (F(2,35.58) = 7.043, p = 0.003, Welch test) lower in 70/30 insulin group (171 ¡À 38 mg/dL) compared to (218 ¡À 71 mg/dL) in SSI group (p = 0.026) and (225 ¡À 65 mg/dL) in glargine/glulisine group (p = 0.01). </span><span style=\"font-family:Verdana;\">Conclusions: </span><span style=\"font-family:Verdana;\">With poorly educated nursing staff, basal plus SS insulin failed to provide adequate glycemic control. However, tailored 70/30 insulin regimen resulted in statistically significant glycemic control compared to traditional SSI.</span></span>
%K Type 2 DM
%K Sliding Scale Insulin
%K 70/30 Insulin
%K Basal Insulin
%K Supplemental Insulin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=38568