%0 Journal Article
%T Influence of the Meal and Genotype of CYP2C19 on the Pharmacokinetics of Proton Pump Inhibitors in Healthy Japanese Subjects
%A Hirohiko Shinkai
%A Tomoyuki Koike
%A Miki Shimada
%A Kenichiro Nakagawa
%A Katsunori Iijima
%A Yotaro Matsumoto
%A Masamitsu Maekawa
%A Nariyasu Mano
%A Tooru Shimosegawa
%J Pharmacology & Pharmacy
%P 502-509
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.46073
%X <span style=\"font-family:Verdana;color:black;font-size:10pt;\">Objectives: </span><span style=\"font-family:'Times New Roman','serif';color:black;font-size:10pt;\"><span style=\"font-family:Verdana;\">To evaluate the influence of meals on the pharmacokinetics of omeprazole and rabeprazole and to investigate these PPIs with reference to CYP2C19 genotypes in healthy Japanese men. </span><span style=\"font-family:Verdana;\">Methods: </span><span style=\"font-family:Verdana;\">This was a randomized, open label, four-way crossover study. Twelve healthy Japanese male volunteers received a single oral dose of either 20 mg omeprazole or 10 mg rabeprazole, in the fasted state and after a standardized breakfast. </span><span style=\"font-family:Verdana;\">Results: </span><span style=\"font-family:Verdana;\">Between the administration of omeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC, Tmax, and half-life. Between the administration of rabeprazole in the fasted state and after breakfast, there were no significant differences in Cmax, AUC and half-life, whereas the Tmax of rabeprazole after breakfast was significantly delayed (2.8 ¡À 1.0 vs 5.3 ¡À 1.8 h, respectively; p = 0.006). PMs demonstrated the highest Cmax and AUC after drug intake under the fasting state and after breakfast, and homo EMs showed a significantly delayed Tmax. </span><span style=\"font-family:Verdana;\">Conclusion: </span><span style=\"font-family:Verdana;\">When a single dose of either PPI was administered, the pharmacokinetics of omeprazole was not affected by the meal, whereas the Tmax of rabeprazole after the meal was significantly delayed.</span></span>
%K Proton Pump Inhibitor
%K Omeprazole
%K Rabeprazole
%K CYP2C19
%K Pharmacokinetics
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36965