%0 Journal Article
%T Trimetazidine and Cellular Response in Cardiopulmonary Bypass*
%A Gerez Fernandes Martins
%A Aristarco G. de Siqueira Filho
%A Jo£¿o Bosco de F. Santos
%A Claudio Roberto Cavalcanti Assun£¿£¿o
%A Alberto Val¨ºncia
%A Gerez Martins
%J World Journal of Cardiovascular Surgery
%P 171-179
%@ 2164-3210
%D 2013
%I Scientific Research Publishing
%R 10.4236/wjcs.2013.35035
%X <b><span>Background</span></b><b><span>:</span></b><span> Organic cellular inflammatory response constitutes a pathophysiological mechanism present in all Coronary Artery Bypass Graftings (CABGs). In this aspect, the organism brings forth its defenses through answers that in</span><span>volve cellular components. <b>Objectives</b></span><b><span>:</span></b><span> To evaluate, in a randomized double-blind prospective study, controlled with placebo, the effects of trimetazidine (Tmz) on cellular response, analyzed through the variation of leukocytes, neutro</span><span>phils and monocytes. <b>Patients and Method</b></span><b><span>:</span></b><span> 30 patients were randomly selected to be studied, with no more than a mild ventricular dysfunction, and divided into two groups (Tmz and placebo) stratified by echocardiography and re</span><span>ceiving medication/placebo in a 60 mg/day dose. </span><span>T</span><span>he samples of leukocytes, neutrophils and monocytes were obtained in the pre-operatory day without medication, at surgery day with 12 to 15 days of medication/placebo, with 5 minutes after the aortic declamping, and within 12, 24 and 48 hours after surgery. <b>Results</b></span><b><span>:</span></b><span> The leukocytes and neutrophils lev</span><span>els have decreased significantly in the treated group when compared to the control group, in all analyzed moments (p = 0.012; p = 0.005). <b>Conclusions and Clinical Implications</b></span><b><span>:</span></b><span> Trimetazidine has proved to reduce significantly the levels of total leukocytes and neutrophils in patients submitted to CABG.</span>
%K Trimetazidine
%K Administration and Dosage
%K Myocardial Reperfusion
%K Inflammation
%K Cellular Re-sponse
%K Myocardial Revascularization
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=37148