%0 Journal Article
%T Evolutionarily conserved features of the retained intron in alternative transcripts of the <i>nxf1</i> (nuclear export factor) genes in different organisms
%A Ludmila A. Mamon
%A Sergey F. Kliver
%A Elena V. Golubkova
%J Open Journal of Genetics
%P 159-170
%@ 2162-4461
%D 2013
%I Scientific Research Publishing
%R 10.4236/ojgen.2013.33018
%X <p>
	<span style=\"font-size:10.0pt;\"><span style=\"font-family:Verdana;\">One of the features of intron-containing genes of
the </span><i><span style=\"font-family:Verdana;\">nxf</span></i><span style=\"font-family:Verdana;\"> (nuclear export factor) family in different organisms is the
presence of an evolutionarily conserved exon-intron block: exon 110nt-intron-exon
37nt. The intron in this evolutionarily conserved block, which we call a
¡°cassette¡± intron, can be excised or retained in alternative transcripts of </span><i><span style=\"font-family:Verdana;\">nxf1</span></i><span style=\"font-family:Verdana;\">.
It corresponds to intron 10 -11 inthe genes that are orthologous to </span><i><span style=\"font-family:Verdana;\">nxf1</span><span style=\"font-style:normal;font-family:Verdana;\"> in</span><span style=\"font-style:normal;font-family:Verdana;\"> vertebrates, and intron 5 -6 inthe genes that are orthologous to </span><span style=\"font-family:Verdana;\">nxf1</span><span style=\"font-style:normal;font-family:Verdana;\"> in</span><span style=\"font-style:normal;\"> </span><span style=\"font-family:Verdana;\">Drosophilidae</span></i><span style=\"font-family:Verdana;\">. </span><span style=\"font-family:Verdana;\">The
alignment of sequences of cassette introns in </span><i><span style=\"font-family:Verdana;\">nxf1</span></i><span style=\"font-family:Verdana;\"> genes in
vertebrates has revealed four evolutionarily conserved sequences: 1)5¡¯flanking sequence, 2) a region
containing </span></span><span style=\"font-size:10pt;font-family:Verdana;\">§³§´§¦</span><span style=\"font-size:10.0pt;\"><span style=\"font-family:Verdana;\"> (constitutive transport element), 3) third conserved sequence, and 4)3¡¯flanking sequence. Introns 5-6 of </span><i><span style=\"font-family:Verdana;\">nxf1</span><span style=\"font-style:normal;font-family:Verdana;\"> in</span><span style=\"font-style:normal;\"> </span><span style=\"font-family:Verdana;\">Drosophilidae</span></i><span style=\"font-family:Verdana;\"> have no similar conserved
sequences. </span><span style=\"font-family:Verdana;\">The results of sequence alignment demonstrate
a similarity between cassette introns of </span><i><span style=\"font-family:Verdana;\">nxf</span></i><i><span style=\"font-family:Verdana;\">1</span></i><span style=\"font-family:Verdana;\"> in </span><i><span style=\"font-family:Verdana;\">Drosophilidae </span></i><span style=\"font-family:Verdana;\">in two poly(A) sequences. The prevalence of </span><i><span style=\"font-family:Verdana;\">Dm
nxf1</span></i><span
%K &lt
%K i&gt
%K Nxf&lt
%K /i&gt
%K Intron Retention
%K CTE
%K Poly(A)
%K &lt
%K i&gt
%K Drosophila&lt
%K /i&gt
%K Vertebrates
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36329