%0 Journal Article
%T A Novel Peptide from T-Cell Leukemia Translocation-Associated Gene (TCTA) Protein Inhibits Proliferation of a Small-Cell Lung Carcinoma
%A Shigeru Kotake
%A Toru Yago
%A Manabu Kawamoto
%A Yuki Nanke
%J Journal of Cancer Therapy
%P 44-46
%@ 2151-1942
%D 2013
%I Scientific Research Publishing
%R 10.4236/jct.2013.48A007
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\" style=\"font-family:Verdana;\">In 2009, we demonstrated that a
peptide, which we named </span><span lang=\"EN-US\" style=\"font-family:Verdana;\">¡°</span><span lang=\"EN-US\" style=\"font-family:Verdana;\">Peptide A</span><span lang=\"EN-US\" style=\"font-family:Verdana;\">¡±</span><span lang=\"EN-US\" style=\"font-family:Verdana;\">,
derived from the extracellular domain of T-cell leukemia
translocation-associated gene (TCTA) protein, inhibited both RANKL-induced
human osteoclastogenesis and pit formation of mature human osteoclasts. Here,
we examine</span><span lang=\"EN-US\" style=\"font-family:Verdana;\">d</span><span lang=\"EN-US\" style=\"font-family:Verdana;\"> the effect of
Peptide A on the cell proliferation of cell lines of small-cell lung carcinoma,
breast cancer, and prostate cancer: RERF-LC-MA, MCF-7, and PC-3, respectively.
Peptide A inhibited the proliferation of RERF-LC-MA, but not MCF-7 or PC-3.
TCTA protein was immunohistologically detected in RERF-LC-MA and MCF-7. Thus,
Peptide A may provide a novel strategy for the therapy of the patients with
small-cell lung carcinoma, especially with bone metastasis. In addition,
Peptide A may be useful for the treatment of various cancer patients with bone
metastasis.</span> 
</p>
%K Osteoclast
%K Small-Cell Lung Carcinoma
%K TCTA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36231