%0 Journal Article
%T Effects of ADH1C, ALDH2, and CYP2A6 Polymorphisms on Individual Risk of Tobacco-Related Lung Cancer in Male Japanese Smokers
%A Makiko Shimizu
%A Yuki Ishii
%A Maho Okubo
%A Hideo Kunitoh
%A Tetsuya Kamataki
%A Hiroshi Yamazaki
%J Journal of Cancer Therapy
%P 29-35
%@ 2151-1942
%D 2013
%I Scientific Research Publishing
%R 10.4236/jct.2013.48A005
%X <p class=\"MsoNormal\" style=\"text-align:justify;\">
	Recent
genome-wide association studies have identified several lung cancer susceptibility
loci. We previously carried out a replication study in male Japanese smokers
that focused on chromosome 5p15 (telomerase reverse transcriptase) and 3q28 (tumor
protein p63) (Shimizu et al., Journal of Cancer Therapy, Vol. 2, No. 5,
2011, pp. 690-696). The current study was performed to
confirm the association of traditional susceptibility loci [i.e., alcohol dehydrogenase <st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"1\" unitname=\"C\">1C</st1:chmetcnv> (ADH<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"1\" unitname=\"C\">1C</st1:chmetcnv>)
and aldehyde dehydrogenase 2 (ALDH2)]
in 1039 male Japanese smokers (573 lung
cancer patients and 466 healthy control
subjects) who were previously enrolled in a study to investigate the low odds
ratio for lung cancer risk associated with functionally impaired and deletion
polymorphisms in cytochrome P450 <st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"2\" unitname=\"a\">2A</st1:chmetcnv>6
(CYP<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"2\" unitname=\"a\">2A</st1:chmetcnv>6). The
minor allele frequency of rs<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"True\" sourcevalue=\"671\" unitname=\"in\">671 in</st1:chmetcnv>
ALDH2 (0.304) was significantly higher
in lung cancer cases than in controls (0.226), with an odds ratio of 1.42 [95%
confidence interval (CI) of 1.12 - 1.80, p = 0.0033]. No significant
association of rs<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"True\" sourcevalue=\"698\" unitname=\"in\">698 in</st1:chmetcnv> ADH<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"1\" unitname=\"C\">1C</st1:chmetcnv> with lung
cancer risk was found in this population of male Japanese smokers. For light
smokers categorized according to the 50th percentile Brinkman index value among
the control subjects (620 daily cigarettes กม years) and for the CYP<st1:chmetcnv w:st=\"on\" tcsc=\"0\" numbertype=\"1\" negative=\"False\" hasspace=\"False\" sourcevalue=\"2\" unitname=\"a\">2A</st1:chmetcnv>6*1
wild-type non-carrier sub-population, significantly high odds ratios of 1.98
and 1.68 (95% CI of 1.28 - 3.06, p = 0.0022, and
%K Alcohol Dehydrogenase 1C
%K Aldehyde Dehydrogenase 2
%K Cytochrome P450 2A6
%K Lung Cancer
%K Tobacco
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36108