%0 Journal Article
%T Testosterone Levels Do Not Decline with Age in Healthy Men
%A Akanksha Mehta
%A Alexander Bolyakov
%A Raymond C. Sultan
%A Laurent Vaucher
%A Anna Mielnik
%A Joseph Kiper
%A Darius A. Paduch
%J Open Journal of Urology
%P 173-178
%@ 2160-5629
%D 2013
%I Scientific Research Publishing
%R 10.4236/oju.2013.34032
%X <p class=\"MsoNormal\">
	<b><span lang=\"EN-US\">Aim: </span></b><span lang=\"EN-US\">To establish norms for reproductive hormones in healthy males with
normal urologic and sexual function, and to assess the change in reproductive
hormon</span><span lang=\"EN-US\">e</span><span lang=\"EN-US\"> levels with respect to age among healthy males. <b>Methods:</b> Healthy volun</span><span lang=\"EN-US\">teers
aged 18</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">-</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">29 (group 1) and 45</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">-</span><span lang=\"EN-US\"> </span><span lang=\"EN-US\">65 (group 2) were recruited for enrollment in a
prospective study. Inclusion criteria comprised normal urinary, ejaculatory,
orgasmic, and erectile function, as determined by IPSS, MSHQ, and IEFF-15. Men
with history of chronic medical illnesses or chronic medication use were
excluded. Fifty men met the study criteria. Each participant underwent physical
examination and standardized serum hormone evaluation using ELISA and EIA
methods. Statistical analysis was performed using JMP 8.0 software (SAS
Institute Inc., <st1:place w:st=\"on\"><st1:city w:st=\"on\">Cary</st1:city>, <st1:state w:st=\"on\">NC</st1:state></st1:place>), to compare hor</span><span lang=\"EN-US\">mone levels between
the two groups of men.<b> Results:</b> There were 25 men each in groups 1 (mean age 26) and 2 (mean age 51). Overall,
46% were Caucasian, 31% African American, 15% Hispanic, and 8% Asian. There was
no statistically significant difference in serum total T, SHBG, E2, or LH
between groups 1 and 2. Notably, the 95% CI for serum T levels for both groups
of men w</span><span lang=\"EN-US\">ere</span><span lang=\"EN-US\"> considerably higher than commonly accepted lower-end cut-off
limits. <b>Conclusion:</b> Serum T levels
do not vary significantly with age, in otherwise healthy men with normal sexual
and urologic function. Furthermore, healthy men have much higher serum total
and free T levels than the lower-end reference limits provided by commercial
laboratories.</span><span lang=\"EN-US\"><o:p></o:p></span> 
</p>
%K Testosterone
%K Aging
%K Hypogonadism
%K Reference Values
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=34977