%0 Journal Article
%T The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on  Expression of NF-百b and MCP-1 in Rats with Silicosis
%A Qian Li
%A Fang Yang
%A Lijuan Zhang
%A Hong Xu
%A Wenli Zhang
%J International Journal of Clean Coal and Energy
%P 24-26
%@ 2168-1538
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijcce.2013.22B006
%X <p>
	In the present study, we developed silicosis of
rat model by bronchial perfusion SiO<span style=\"white-space:nowrap;\"><sub>2</sub></span> dust, and intervenes with
AcSDKP, immunohisto chemistry was used to detect NF-百b and MCP-1 expression in lung
tissue, and positive cells were counted. We found that compared with silicotic
model group, the positive cells of NF-百b and MCP-1 were decreased significantly
in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-百b
and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of
macrophage infiltration in lung tissue and reduced the degree of dust
alveolitis.
</p>
%K N-acetyl-seryl-aspartyl-lysyl-proline
%K Silicosis
%K Monocyte Chemotactic Protein-1
%K Nuclear Factor-百b
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=35157