%0 Journal Article
%T Identification and Localization of Prostate Cancer with Combined Use of T2-Weighted, Diffusion Weighted MRI and Proton MR Spectroscopy, Correlation with Histopathology
%A Baki Hekimo£¿lu
%A Hasan Aydin
%A Volkan K£¿z£¿lg£¿z
%A £¿dil G¨¹ne£¿ Tatar
%A Ali R£¿za Ugan
%A £¿rem Paker
%J Advances in Molecular Imaging
%P 23-36
%@ 2161-6752
%D 2013
%I Scientific Research Publishing
%R 10.4236/ami.2013.33005
%X <b><span>Purpose</span></b><b><span>: </span></b><span>To predict the diagnostic performance of combined use of T2-</span><span>weighted imaging</span><span> </span><span>(T2W)</span><span>-</span><span>diffusion weighted MRI</span><span> </span><span>(DWI)</span><span> </span><span>and apparent diffusion coefficient</span><span> </span><span>(ADC)-proton MR spectroscopy</span><span> </span><span>(H-MRS)</span><span> for the detection of prostate cancer, correlated to histopathology as the reference standard.</span><span> </span><b><span>Method</span></b><b><span>:</span></b><span> After institutional review board approval<span>,<i> </i></span>40 patients with prostate cancer were included in this retrospective research. Two readers evaluated the results of T2W, DWI-ADC mapping and H-MRS independently for the depiction of prostate cancer. Reference standard was the TRUS-</span><span>guided biopsy and the surgical histopathological results. Statistical analysis was assessed by Fisher¡¯s exact t-test, Wilcoxon signed rank test, variance analysis test with Kappa (k) values<b> </b>and<b> </b>receiver operating characteristics (ROC) curve for ADC values, Cho/Cit and Cho</span><span> </span><span>+</span><span> </span><span>Cre/Cit ratios for each observer.<span> <b>Results</b></span></span><b><span>:</span></b><span> Both readers declined </span><span>46% sensitivity and 68% specificity for T2W sequence, 29% sensitivity and 82% specificity for DWI-ADC mapping and 49% specificity for </span><span>Cho/Cit and Cho</span><span> </span><span>+</span><span> </span><span>Cre/Cit </span><span>ratios, 69% sensitivity for </span><span>Cho/Cit 70% sensitivity for Cho</span><span> </span><span>+</span><span> </span><span>Cre/Cit ratios of H-MRS.</span><b><span> </span></b><span>T2W</span><span> </span><span>+</span><span> </span><span>DWI-ADC mapping</span><span> </span><span>+</span><span> </span><span>H-MRS (</span><span>Cho/Cit and Cho</span><span> </span><span>+</span><span> </span><span>Cre/Cit ratios) regarded 81% sensitivity and 66% specificity, with significant statistical differences to the reference histopathology</span><span> </span><span>(p</span><span> </span><span>&lt;</span><span> </span><span>0.05). <b>Conclusion</b></span><b><span>:</span></b><span> Combination of T2W, DWI and H-MRS were more sensitive and more accurate than either sequences alone, for prostate cancer localization and detection.</span><span></span>
%K MRI
%K Prostate Cancer
%K DWI
%K H-MRS
%K T2W
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=33978