%0 Journal Article
%T A Facile Synthesis of 9,10-Dimethoxybenzo[6,7]- ox-epino[3,4-<i>b</i>]quinolin-13(6<i>H</i>)-one and Its Derivatives
%A Dingqiao Yang
%A Xiuli Liang
%A Xiongjun Zuo
%A Yuhua Long
%J International Journal of Organic Chemistry
%P 119-124
%@ 2161-4695
%D 2013
%I Scientific Research Publishing
%R 10.4236/ijoc.2013.32013
%X <p class=\"MsoNormal\">
	<span style=\"font-family:Verdana;\">A concise
and efficient method for the synthesis of novel 9,10-imethoxybenzo[6,7]oxepino[3,4-</span><i><span style=\"font-family:Verdana;\">b</span></i><span style=\"font-family:Verdana;\">]quinolin13(6</span><i><span style=\"font-family:Verdana;\">H</span></i><span style=\"font-family:Verdana;\">)-one and
its derivatives 7a-p has been developed via the
intramolecular Friedel-Crafts acylation reactions of 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic
acids 6a-p with polyphosphoric
acid (PPA) as catalyst and solvent under mild conditions. The key intermediates
6a-p were prepared through the </span><i><span style=\"font-family:Verdana;\">in situ</span></i><span style=\"font-family:Verdana;\"> formation of ethyl 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylates
5a-p followed by hydrolysis
with aqueous ethanolic sodium hydroxide
solution. The novel synthetic method has the advantages of good yields, easy
work-up, and environmentally friendly character, which may provide a novel
highly efficient process for making quinoline and related azaheterocycle
libraries.</span> 
</p>
%K The Intramolecular Friedel-Crafts Acylation Reaction: 9
%K 10-Dimethoxybenzo
%K [6
%K 7]oxepino[3
%K 4-&lt
%K i&gt
%K b&lt
%K /i&gt
%K ]quinolin-13(6&lt
%K i&gt
%K H&lt
%K /i&gt
%K )-one and Its Derivatives
%K 6
%K 7-Dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic Acid: Ethyl
%K 6
%K 7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylate: PPA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=32999