%0 Journal Article
%T Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses
%A Kristian M. Hargadon
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 7-27
%@ 2161-4512
%D 2013
%I Scientific Research Publishing
%R 10.4236/jcdsa.2013.32A002
%X <p class=\"MsoNormal\">
	<span lang=\"EN-US\">Melanoma is the most aggressive form
of skin cancer and accounts for the vast majority of skin cancer-related
deaths. Its ability to metastasize quickly, often before diagnosis, makes this
cancer difficult to treat with traditional therapies. The identification of
anti-melanoma immune responses in patients and the discovery of tumor antigens
targeted by these immune responses have paved the way for immunotherapy as a
novel approach to treating this cancer. In this review, the major
immunotherapies targeting these melanoma tumor antigens are discussed. The
advantages and limitations of peptide-, protein-, and gene-based vaccination
maneuvers and adoptive cell transfer therapies are emphasized. Recent insights
into melanoma immune evasion strategies are also highlighted, with particular
focus on how our increasing knowledge of tumor/immune cell interactions is
driving the development of novel immunotherapeutic strategies for the treatment
of melanoma.</span><span lang=\"EN-US\"><o:p></o:p></span> 
</p>
%K Melanoma
%K Tumor Immunotherapy
%K Dendritic Cell
%K Tumor Antigen
%K T Cell
%K Vaccine
%K Adoptive Transfer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=33333