%0 Journal Article %T Do Cytokines Play a Role in Predicting Some Features and Outcome in Infective Endocarditis? %A Maria Carmo Pereira Nunes %A Izabella Rodrigues de Ara¨²jo %A Andr¨¦a Teixeira de Carvalho %A Let¨ªcia Alves Andrade %A Marcio Henrique Lima Resende %A Jos¨¦ Luiz Padilha da Silva %A Teresa Cristina Abreu Ferrari %J Advances in Infectious Diseases %P 115-119 %@ 2164-2656 %D 2013 %I Scientific Research Publishing %R 10.4236/aid.2013.32018 %X

Objective: This study aimed to measure the serum concentrations of several cytokines in patients with infective endocarditis (IE), and correlate them with the C-reactive protein serum levels, echocardiographic findings and infecting microorganisms. Methods: Forty-five patients with definite IE according to the Duke¡¯s criteria were included in the study. Ten healthy blood donors formed the control group. Serum levels of interleukin (IL) 1¦Â, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor-¦Á (TNF-¦Á) were measured and compared between the groups, and also with some clinical and laboratory parameters of IE. Results: Patients with IE had significantly higher serum concentrations of the inflammatory mediators than the control patients. Median IL-12 and IL-1¦Â levels were higher in staphylococcal than streptococcal IE. Except for TNF-¦Á, the levels of all the other cytokines correlated with the C-reactive protein concentrations. In multivariate analysis, IL-10 and IL-12 serum levels remained as independent factors associated with the C-reactive protein concentrations. There was a significant correlation between IL-10 concentration and vegetation length. Conclusion: The inflammatory serum cytokines levels were elevated in IE in comparison to healthy controls. C-reactive protein concentrations correlated with cytokines levels. IL-1¦Â and IL-12 serum concentrations were higher in staphylococcal when compared to streptococcal IE. IL-10 levels were associated with vegetation size.

%K Infective Endocarditis %K Inflammatory Cytokines %K C-Reactive Protein %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=32830