%0 Journal Article
%T Bacterial UDP-Glucose Hydrolases and P2 Receptor-Mediated Responses to Infection: A Commentary
%A Ifor R. Beacham
%A John P. Headrick
%J Advances in Infectious Diseases
%P 100-104
%@ 2164-2656
%D 2013
%I Scientific Research Publishing
%R 10.4236/aid.2013.32016
%X <p class=\"MsoNormal\">
	<span lang=\"EN-AU\">UDP-glucose hydrolases are a group of relatively little known
membrane-bound or periplasmic enzymes found in <i>Salmonella enterica</i> and <i>E.
coli</i>. UDP-glucose is an agonist for a specific P2 receptor (P2Y<sub>14</sub>)
found on epithelial cells and cells associated with innate immunity. It is also
recognised as a ¡®danger signal¡¯. Cells respond to mechanical damage by
releasing UDP-glucose which activates P2Y<sub>14</sub> to trigger an innate
immune response; it is postulated that a similar response to bacterial
infection may be protective against infection. However, the UDP-glucose
hydrolases may constitute virulence factors able to abrogate this response by
degradation of the released UDP-glucose.</span> 
</p>
%K UDP-Glucose Hydrolase
%K P2Y14 Receptor
%K Virulence Factor
%K &lt
%K i&gt
%K Salmonella enterica&lt
%K /i&gt
%K &lt
%K i&gt
%K E. coli&lt
%K /i&gt
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=32635