%0 Journal Article
%T Evaluation of the Efficacy and Safety of 1% Sodium Chloride (LiceFreee Spray) against 1% Permethrin Crème Rinse on Head Lice Infested Individuals
%A Lidia Serrano
%A Lorraine S. Decesar
%A Loan Pham
%J Pharmacology & Pharmacy
%P 266-273
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.42038
%X <span style=\"font-size:10pt;font-family:Verdana;\">Head
lice are a public health issue, and </span><span style=\"font-size:10pt;font-family:Verdana;\">resistance to available over-the-counter pediculicides
is a concern. </span><span style=\"font-size:10pt;font-family:Verdana;\">The objective of this randomized
study was to evaluate the pediculicidal activity and safety of </span><span style=\"font-size:10pt;font-family:Verdana;\">1% Sodium Chloride spray (0.1709
M), (LiceFreee Spray</span><sup><span style=\"font-size:10pt;font-family:Verdana;\"><span style=\"font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;\">?</span></span></sup><span style=\"font-size:10pt;font-family:Verdana;\">)</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10pt;font-family:Verdana;\">compared
to the current recommended treatment for head lice with </span><span style=\"font-size:10pt;font-family:Verdana;\">1% Permethrin Cr¨¨me Rinse</span><span style=\"font-size:10pt;font-family:Verdana;\">. </span><span style=\"font-size:10pt;font-family:Verdana;\">Forty-two subjects were randomized equally into Sodium
Chloride </span><span style=\"font-size:10pt;font-family:Verdana;\">or </span><span style=\"font-size:10pt;font-family:Verdana;\">Permethrin </span><span style=\"font-size:10pt;font-family:Verdana;\">group. Products were </span><span style=\"font-size:10pt;font-family:Verdana;\">applied to hair according to the label instructions.
After application of the products at Day 1 and Day 8, pediculicidal efficacy
and safety were assessed at Day 1, Day 8 and Day 15. Second treatment was only
applied on Day 8 to individuals with </span><span style=\"font-size:10pt;font-family:Verdana;\">ob</span><span style=\"font-size:10pt;font-family:Verdana;\">served live lice using the same
products and protocols as Day 1. Proportion of lice free subjects per group,
the reduction in number of live lice per head and adverse effects were recorded
after each visit. The results showed </span><span style=\"font-size:10pt;font-family:Verdana;\">significantly higher pediculicidal activity for Sodium
Chloride </span><span style=\"font-size:10pt;font-family:Verdana;\">spray</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10pt;font-family:Verdana;\">(85%)
as compared to Permethrin (45%) at Day 15 (p</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10pt;font-family:Verdana;\">&lt;</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">
%K Head Lice
%K Sodium Chloride
%K LiceFreee Spray&#174
%K Nix&#174
%K Permethrin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=30398