%0 Journal Article
%T Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine
%A Yuka Takasugi
%A Futoshi Kurai
%A Issei Kazume
%A Masaki Otsuka
%A Yoichi Negishi
%A Rui Tada
%A Yukihiko Aramaki
%J Pharmacology & Pharmacy
%P 248-254
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.42035
%X <span style=\"font-size:10pt;font-family:Verdana;\">We have recently demonstrated that liposomes
composed of phosphatidylserine (PS-liposomes) suppressed nitric oxide and
inflammatory cytokine productions following LPS stimulation in macrophages. In
this study, we examined the effect of PS-liposomes on expressions of TLR-4 and
MyD88, which are essential for the signal transduction in LPS stimulation. Expression
of MyD88 was suppressed when macrophages were treated with PS-liposomes, but
not with liposomes of phosphatidylcholine. No change in TLR-4 expression was
observed. MyD88 suppression was restored to the control levels when cells were
pre-treated with anti-TGF-</span><i><span style=\"font-size:10pt;font-family:Verdana;\">¦Â</span></i><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10pt;font-family:Verdana;\">antibody, suggesting that TGF-</span><i><span style=\"font-size:10pt;font-family:Verdana;\">¦Â</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span></i><span style=\"font-size:10pt;font-family:Verdana;\">plays an important role in down-regulation of MyD88
following PS-liposome treatment.</span>
%K Phosphatidylserine
%K Liposome
%K MyD88
%K TGF-¦Â
%K Macrophage
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=30395