%0 Journal Article
%T Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications
%A Kathryn Grandfield
%A Shiuli Pujari
%A Marjam Ott
%A H£¿kan Engqvist
%A Wei Xia
%J Journal of Biomaterials and Nanobiotechnology
%P 107-113
%@ 2158-7043
%D 2013
%I Scientific Research Publishing
%R 10.4236/jbnb.2013.42014
%X Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m2/g, as measured by N2 adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.
%K Mesoporous
%K Titania
%K Calcium
%K Strontium
%K Drug Delivery
%K Bone
%K EISA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=29699