%0 Journal Article
%T Efficacy of Drugs Used in Gastro-Oesophageal Reflux: Network Meta-Analysis
%A Rafael Bola£¿os-D¨ªaz
%A H¨¦ctor Velarde-Criado
%A Erik C¨®ndor-Mori
%J Pharmacology & Pharmacy
%P 201-208
%@ 2157-9431
%D 2013
%I Scientific Research Publishing
%R 10.4236/pp.2013.42028
%X Introduction: It is important to rank the clinical efficacy of different anti-reflux agents to promote their rational use. Objective: To combine the results of randomized clinical trials that have compared the incidence of symptoms related to gastro-oesophageal reflux (GER) with/without endoscopic evidence of oesophagitis in a network meta-analysis and thus rank the main anti-reflux therapies according to the magnitude of their clinical efficacy. Method: Inclusion criteria: 1) randomized controlled trials that compare anti-reflux agents (alginates (ALG), proton-pump inhibitors (PPI), H2 histamine receptor antagonists (H2RA), antacids (AA), gastrokinetics (GK)) in open designs as compared to placebo or in comparative designs (head-to-head); 2) outcome of interest measured in some scale representing the significant improvement of reflux symptoms; 3) GER diagnosis with/without oesophagitis endoscopic evidence. We collected available clinical trials for each one of the direct comparisons. The Odds Ratio (OR) was used additionally to calculating lnOR and its Standard Error (SE[lnOR]) to
%K Gastro-Oesophageal Reflux
%K Network
%K Meta-Analysis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=29751