%0 Journal Article
%T Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity
%A Amy L. Adamson
%J Open Journal of Genetics
%P 1-5
%@ 2162-4461
%D 2013
%I Scientific Research Publishing
%R 10.4236/ojgen.2013.31001
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10pt;\"><span style=\"font-size:12px;\">Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the worldĄŻs adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in </span><i><span style=\"font-size:12px;\">Drosophila melanogaster</span></i><span style=\"font-size:12px;\"> to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the </span><i><span style=\"font-size:12px;\">Drosophila melanogaster</span></i> <i><span style=\"font-size:12px;\">CG9384</span></i><span style=\"font-size:12px;\"> gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication. </span></span> 
</p>
%K Epstein-Barr Virus
%K BZLF1
%K &lt
%K i&gt
%K Drosophila&lt
%K /i&gt
%K &lt
%K i&gt
%K CG9384&lt
%K /i&gt
%K Gnt-IVb
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=28998