%0 Journal Article
%T FTO genotype is associated with body mass index and waist circumference in Mexican young adults
%A Margarita Teran-Garcia
%A Itzel Vazquez-Vidal
%A Flavia C. D. Andrade
%A Michelle Mosley
%A Eduardo Medina-Cerda
%A Celia Aradillas-Garcia
%J Open Journal of Genetics
%P 44-48
%@ 2162-4461
%D 2013
%I Scientific Research Publishing
%R 10.4236/ojgen.2013.31005
%X <p style=\"text-align:justify;\">
	<span style=\"font-size:10pt;\"><span style=\"font-size:12px;\">Individual variations in the fat mass and obesity-associated (FTO) gene have been associated with obesity and BMI in diverse populations, but there are no reports in young Mexicans. We explored the association of a common FTO single-nucleotide polymorphism (SNP, rs805704) with obesity-related phenotypes in Mexican young adults. The FTO-SNP was genotyped using the fluorescent polarization method in college-age, apparently healthy subjects from the ˇ°UP AMIGOSˇ± cohort (n = 251, 18 - 25 yrs). Homozygotes for the A allele (15%, n = 38) were heavier (1.6 kg/m</span><sup><span style=\"font-size:12px;\">2</span></sup><span style=\"font-size:12px;\"> and6.2 kg) and had a larger waist circumference (WC,4.8 cm) than G allele carriers. The FTO genotype was associated with BMI, weight and WC independently of age and sex and explained 2.7 to 3.1% of the variance in obesity-related phenotypes. The FTO genotype was also associated with fasting glucose (P = 0.0283). No other associations were found in the additive model. Despite our small sample size, we found that the FTO-rs805704 genotype influences obesity-related phenotypes young Mexicans. Previously observed FTO associations with fasting glucose were replicated. Previously reported associations with other metabolic traits likely represent the long-term consequences of obesity.</span></span> 
</p>
%K FTO
%K Obesity
%K Genetic Risk
%K Young
%K Mexicans
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=29008