%0 Journal Article
%T Effects of Single Administered Bofutsushosan-Composed Crude Drugs on Diabetic Serum Parameters in Streptozotocin-Induced Diabetic Mice
%A Qing Yu
%A Tatsuo Takahashi
%A Masaaki Nomura
%A Mai Yasuda
%A Kyoko Obatake-Ikeda
%A Shinjiro Kobayashi
%J Chinese Medicine
%P 24-31
%@ 2151-1926
%D 2013
%I Scientific Research Publishing
%R 10.4236/cm.2013.41005
%X <p align=\"justify\">
	<span><span style=\"font-family:Verdana;\">The 18 crude drugs in Bofutsushosan (BOF: </span><i><span style=\"font-family:Verdana;\">Pulvis ledebouriellae compositae</span></i><span style=\"font-family:Verdana;\">: </span></span><span style=\"font-family:Verdana;\">·ÀïLͨÂ}É¢</span><span style=\"font-family:Verdana;\">) are separated into 6 groups such as diaphoretic, cathartic, antidote, antipyretic, neutralizer and diuretic groups. The effects of single admin</span><span style=\"font-family:Verdana;\">ist</span><span style=\"font-family:Verdana;\">er</span><span style=\"font-family:Verdana;\">ed BOF and composed crude drugs in 6 groups were investigated on the levels of diabetic parameters (serum glu</span><span style=\"font-family:Verdana;\">cose, insulin, triglyceride and cholesterol) in streptozotocin-induced diabetic mice. The anti-hyperglycemic action of BOF was depended on Ephedrae Herba, Saposhnikoviae Radix and Schizonepetae Spica in diaphoretic group, For</span><span style=\"font-family:Verdana;\">sythiae Fructus</span><span style=\"font-family:Verdana;\">, Saposhnikoviae Radix, Schizonepetae Spica </span><span style=\"font-family:Verdana;\">and Cnidii Rhizoma in antidote group, Scutellariae Radix, Gardeniae Fructus</span><span style=\"font-family:Verdana;\"> and</span><span style=\"font-family:Verdana;\"> Gypsum Fibrosum in antipyretic group</span><span style=\"font-family:Verdana;\"> and </span><span style=\"font-family:Verdana;\">Paeoniae Radix</span><span style=\"font-family:Verdana;\"> in </span><span style=\"font-family:Verdana;\">neutralizer</span><span> </span><span style=\"font-family:Verdana;\">group. In these crude drugs, Ephedrae Herba, Saposhnikoviae Radix, Schizonepetae Spica, Forsythiae Fructus, Scutellariae Radix, Gypsum Fibrosum and Paeoniae Radix increased serum insulin level, but Cnidii Rhizoma and Gardeniae Fructus did not affect serum insulin level. From these results, it suggested that anti-hyperglycemi</span><span style=\"font-family:Verdana;\">c</span><span style=\"font-family:Verdana;\"> action of BOF was through insulin-de</span><span style=\"font-family:Verdana;\">pendent and insulin independent manners. The lowering effect of BOF on serum triglyceride level was dependent on actions of Platycodi Radix in antidote and diuretic groups and Gardeniae Fructus in antipyretic group. The lowering effect of Gardeniae Fructus was parallel with its anti-hyperglycemic action. The lowering effect of BOF on high serum triglyceride level also included both direct action and indirect action. The reducing effect of
%K Bofutsushosan (BOF)
%K 6 Groups in BOF (Diaphoretic
%K Cathartic
%K Antidote
%K Antipyretic
%K Neutralizer and Diuretic Groups)
%K Streptozotocin (STZ)
%K Diabetic Serum Parameters
%K Anti-Hyperglycemia
%K Anti-Hyperlipidemia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=28820