%0 Journal Article
%T Imatinib mesylate treatment for platelet-derived growth factor receptor alfa-positive choroid plexus carcinoma
%A Chihiro Kawakami
%A Akiko Inoue
%A Kimitaka Takitani
%A Motomu Tsuji
%J Clinics and Practice
%D 2012
%I PAGEPress Publications
%R 10.4081/cp.2012.e49
%X We herein report a female child with choroid plexus carcinoma treated with standard dose of imatinib at disease recurrence. This patient failed initial twice-surgical resections, central nervous system (CNS) irradiation, and adjuvant chemotherapies and high-dose thiotepa and melphalan with auto peripheral blood stem cell rescue. Finally, imatinib treatment was undergone as a palliative setting, however the tumor did not reduce and the patient died of tumor bleedings. We consider that the reasons for the failure are as follows: i) adequate CNS level of imatinib were not obtained because of the blood brain barrier, ii) the lack of plateletderived growth factor receptor beta expression in our case may have a crucial role.
%K imatinib mesylate
%K platelet derived growth factor receptor (PDGFR) alfa
%K choroid plexus carcinoma.
%U http://www.clinicsandpractice.org/index.php/cp/article/view/441