%0 Journal Article
%T THE STUDY ON THE EFFECT OF FORMULATION VARIABLES ON IN VITRO FLOATING TIME AND THE RELEASE PROPERTIES OF A FLOATING DRUG DELIVERY SYSTEM BY A STATISTICAL OPTIMIZATION TECHNIQUE
%A C. NARENDRA
%A M. S. SRINATH
%A A. MOIN
%J Chemical Industry and Chemical Engineering Quarterly
%D 2008
%I Association of the Chemical Engineers
%X The present investigation concerns the evaluation of the effect of formulation variables on in vitro floating time and the release properties in developing a floating drug delivery system (FDDS) containing a highly water soluble drug metoprolol tartrate (MT) in the presence of a gas generating agent. A 32 full factorial design was employed in formulating the FDDS containing hydroxyl propylmethylcellulose (HPMC K4M) and sodium carboxymethylcellulose (NaCMC) as swellable polymers. Drug-to-polymer ratio and polymer-to-polymer ratio were included as independent variables. The main effect and the interaction terms were quantitatively evaluated by a quadratic model to predict formulations with the floating time desired, and the release properties. It was found that only drug-to-polymer ratio and its quadratic term were found to be significantly affective for all the response variables. Non-Fickian transport was confirmed as a release mechanism from the optimized formulations. The desirability function was used to optimize the response variables, each having a different target, and the observed responses were highly agreed with experimental values. The results demonstrate the feasibility of the model in the development of FDDS containing a highly water-soluble drug MT.
%K Metoprolol tartrate
%K floating drug delivery system
%K HPMC
%K NaCMC
%K factorial design
%K optimization
%U http://www.ache.org.yu/CICEQ/2008/No1/04_2986_2008.pdf