%0 Journal Article
%T Comparison between 0.08% Ropivacaine and 0.06% Levobupivacaine for Epidural Analgesia during Nulliparous Labor: A Retrospective Study in A Single Center
%A Hui-Ling Lee
%A Liang-Ming Lo
%A Chung-Chuan Chou
%A Eng-Chye Chuah
%J Chang Gung Medical Journal
%D 2011
%I 
%X Background: Levobupivacaine and ropivacaine are new local anesthetics that have effectssimilar to bupivacaine. However, the relative potency of these two drugs iscontroversial. The purpose of this retrospective study was to assess whether acombination of 0.06% levobupivacaine and 0.0002% fentanyl had the sameeffects as 0.08% ropivacaine and 0.0002% fentanyl on the mode of deliveryand other obstetric outcomes when used for epidural analgesia of labor innulliparous women.Methods: Computer records of 392 Asian nulliparous parturients, who had presentedwith spontaneous labor or spontaneous rupture of the membranes, and hadreceived epidural analgesia were retrospectively reviewed. Of these, 193received 0.08% ropivacaine and 199 received 0.06% levobupivacaine.Fentanyl (0.0002%) was used in both regimens.Results: There were no significant differences in the mode of delivery, duration oflabor, or neonatal outcome between the two groups. In the levobupivacainegroup, the parturients required top-up boluses of local anesthetics more frequently (1.4   1.6 vs. 0.9   1.3, p < 0.0001), and the incidence of temporary maternal fever (25% vs. 15%, p = 0.024) and the cost of local anestheticwere higher (292   183 NTD vs. 146   104 NTD, p < 0.0001). However,the amount of local anesthetic administered during labor was lower (79   49mg vs. 114   81 mg, p < 0.0001) than for the ropivacaine group.Conclusions: 0.06% levobupivacaine was as effective as 0.08% ropivacaine, when bothwere used with 0.0002% fentanyl for labor epidural analgesia of nulliparouswomen.
%K epidural analgesia
%K ropivacaine
%K levobupivacaine
%U http://memo.cgu.edu.tw/cgmj/3403/340307.pdf