%0 Journal Article
%T Comparing Late-onset and Neonatally-diagnosed Congenital Cystic Adenomatoid Malformation of the Lung
%A Sui-Ling Liao
%A Shen-Hao Lai
%A Chuen Hsueh
%A Kin-Sun Wong
%J Chang Gung Medical Journal
%D 2010
%I 
%X Background: Most congenital cystic adenomatoid malformations (CCAM) are found inutero or during the immediate neonatal period. Some malformations regressin utero, while others persist and remain unnoticed until later in childhood.The optimal clinical management of patients with CCAM is controversial.The aim of this study is to suggest a safe strategy for treatment of CCAMbased upon the age of the patient at diagnosis, by analyzing the clinical featuresof CCAM and considering the possibility of regression in early infancy.Method: This is an observational retrospective study of 19 patients with CCAM. Theclinical features, histopathological classification, status of lesion regression,diagnostic method, treatment, and outcome were collected. Patient data wereanalyzed highlighting age at disease presentation.Results: Five out of the seven neonates with neonatally-diagnosed CCAM presentedwith respiratory distress. Eight of the twelve patients in the late-onset grouphad respiratory tract infections. Regression of the lesion during the earlypostnatal period was documented in 4 neonatally-diagnosed CCAMs, whilenone of the patients in the late-onset group showed signs of radiographicchanges after a mean follow up of 4 years. Skeletal malformation was themost common associated anomaly in our series.Conclusion: Conservative treatment is suggested for neonatally-diagnosed CCAMbecause of possible postnatal remission. Surgery may be required in olderpatients because of possible recurrent infections, infrequent mass regression,radiation exposure, and inconveniencies during follow-up visits. A thoroughsurvey of possible associated skeletal anomalies in patients with CCAM isalso recommended as early correction can improve life quality.
%K congenital cystic adenomatoid malformation
%K congenital pulmonary airway malformation
%K cystic lung lesion
%K late-onset
%K neonates
%U http://memo.cgu.edu.tw/cgmj/3301/330104.pdf