%0 Journal Article
%T Asthma Control in Asthmatic Patients Treated for Lung Cancer
%A Chung-Hsing Hsieh
%A Chun-Hua Wang
%A Han-Pin Kuo
%A Kang-Yun Lee
%J Chang Gung Medical Journal
%D 2011
%I 
%X Background: The balance of the Th1 and Th2 immune response plays an important role inthe regulation of the immune system and in general health. Tumor bearinghosts are supposed to have a balance shifting to the Th2 pathway, while afavorable Th1 anti-tumor pathway is induced in tumor-resected hosts. Theclinical impacts of a tumor-related Th2 environment have not been clearlystudied. The present study was conducted to test the hypothesis that nonsmallcell lung cancer (NSCLC) has an impact on control of asthma, a wellknownTh2-predominant inflammatory disease.Method: Thirty-eight patients with the diagnoses of both asthma and lung cancer wereretrospectively enrolled. Patients were divided into two groups according totheir response to lung cancer treatment, the responder group (completeregression, partial regression and stable disease) and non-responder group(progression of disease). Asthma control test (ACT) scores were analyzedone year before diagnosis, at the time of diagnosis of lung cancer, and at thetime of re-staging after cancer treatment.Results: All the asthmatics with lung cancer had worsening of their symptomsaccording to their ACT scores at the time of diagnosis of lung cancer comparedto scores in the preceding year (21.6
%K lung cancer
%K lung cancer treatment
%K asthma
%K asthma control
%K Th2 predominant disorder
%U http://memo.cgu.edu.tw/cgmj/3401/340103.pdf