%0 Journal Article
%T Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma
%A Eric H.L. Lee
%A Raj Chari
%A Andy Lam
%A Raymond T. Ng
%J Clinical Medicine : Oncology
%D 2008
%I 
%X Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the transcript level patterns of genes in the Wnt pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was found that over half of the samples examined exhibited dysregulated gene expression of multiple components of the non-canonical branch of the WNT pathway. In the cases where beta catenin (CTNNB1) was not over-expressed, we identified strong relationships of expression between wingless-type MMTV integration site family member 5A (WNT5A)/frizzled homolog 2 (FZD2), frizzled homolog 3 (FZD3)/dishevelled 2 (DVL2), and low density lipoprotein receptor-related protein 5 (LRP5)/secreted frizzled-related protein 4 (SFRP4). This is one of the first studies to demonstrate expression of genes in the non-canonical pathway in normal lung tissue and its disruption in lung squamous cell carcinoma. These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported
%K WNT pathway
%K lung cancer
%K gene expression
%K NSCLC
%K non-canonical
%K squamous cell carcinoma
%U http://la-press.com/article.php?article_id=682