%0 Journal Article
%T Cyclooxygenase-2 in Cardiovascular Biology
%A Joseph F. Murphy
%J Clinical Medicine : Cardiology
%D 2008
%I 
%X Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2. Generally, the COX-1 enzyme is produced constitutively (e.g. in gastric mucosa), whereas COX-2 is highly inducible (e.g. at sites of inflammation and cancer). Traditional non-steroidal anti-inflammatory drugs (NSAIDs) inhibit both enzymes, and a new class of COX-2 selective inhibitors (COXIBs) preferentially inhibit the COX-2 enzyme. This review summarizes our current understanding of the role of COX-1 and COX-2, with emphasis on their role on cardiovascular biology.
%K Cyclooxygenase
%K non-steroidal anti-inflammatory drugs
%K cardiovascular biology
%K angiogenesis.
%U http://www.la-press.com/article.php?article_id=782