%0 Journal Article
%T Anti-N-methyl-D-aspartate receptor encephalitis: a new autoimmune encephalitis
%A CHEN Xiang-jun
%A LI Xiang
%J Chinese Journal of Contemporary Neurology and Neurosurgery
%D 2013
%I Tianjin Huanhu Hospital
%R 10.3969/j.issn.1672-6731.2013.01.005
%X Anti-N-methyl-D-aspartate (anti-NMDA ) receptor encephalitis is a new category of treatable encephalitis associated with anti-NMDA receptor antibody, which attracts more and more attention recently. It is clinically characterized by prodromal fever, schizophrenia-like psychiatric symptoms, seizures, disturbance of consciousness, dyskinesia (particularly orofacial), and autonomic dysfunction, which often occur in young females with ovarian teratomas. Autoantibodies to the anti-NMDA receptor in serum and cerebrospinal fluid are positive. Electroencephalogram (EEG) often reveals diffuse ¦Ä slowing without paroxysmal discharges, on which " ¦Ä rush" is considered as specific characteristic in some patients. Combined therapy including tumor resection and immunotherapy is recommended. The updates in mechanisms, clinical manifestations and diagnostic examinations associated with anti-NMDA receptor encephalitis will be discussed in this review.
%K Receptors
%K N-methyl-D-aspartate
%K Encephalitis
%K Autoimmune diseases
%K Review
%U http://www.cjcnn.org/index.php/cjcnn/article/view/640