%0 Journal Article
%T Gastric cancer and the search for a good prognostic classification: a challenge
%A Esther U&ntilde
%A a Cid&oacute
%A n
%J Clinical and Experimental Gastroenterology
%D 2010
%I Dove Medical Press
%X Esther U a Cid¨®nMedical Oncology Service, Clinical University Hospital of Valladolid, Valladolid, SpainIntroduction: Gastric cancer is the second most common cancer worldwide. The standard -treatment is radical surgical resection, but 60% of patients will present recurrence. TNM -classification (6th edition, American Joint Committee on Cancer) recommends the removal of at least 15 regional lymph nodes to carry out an adequate pathological staging. But in our -environment, only 20% of cases have the minimum recommended, so it would be very -important to have an alternative prognostic. We designed a retrospective study to evaluate different -prognostic factors in patients inadequately staged.Material and methods: We focused on patients with serosal involvement (pT3). The evaluation included general parameters such as age, sex, tumor site, histological type, type of gastrectomy, histological grade, number of nodes analyzed </¡Ý 10, lymph node ratio (LNR) with a 20% cutoff value, and adjuvant treatment. The association between clinicopathological variables and recurrence was investigated by univariate and multivariate logistic regression. It was considered statistically significant with P < 0.05. Results: A total of 92 patients who met the criteria were studied. Median age 65 years; 68% men, 32% women; median follow-up time for the overall population, 44 months (range 15¨C119 months); number of nodes analyzed, median 7 (range 0¨C14 nodes); recurrence in 59%; median time to recurrence, 15 months (range 3¨C48 months); the cumulative risk of relapse at five years, 64%. Multivariate statistical analysis showed that the LNR (P = 0.03) and total number of nodes analyzed </¡Ý 10 (P = 0.04) were independent predictors for the risk of recurrence.Conclusion: LNR and total number of nodes analyzed with a threshold of 10 (</¡Ý 10 nodes analyzed) were independent predictors of recurrence in patients with gastric carcinoma pT3 and an insufficient number of nodes examined.Keyword: pathological classification
%U http://www.dovepress.com/gastric-cancer-and-the-search-for-a-good-prognostic-classification-a-c-a4895