%0 Journal Article
%T Nizatidine Improves Impaired Salivary Secretion in GERD
%A Yoshihisa Urita
%A Toshiyasu Watanabe
%A Kazuo Hike
%A Makie Nanami
%J Clinical Medicine : Case Reports
%D 2008
%I 
%X During esophageal acid clearance, salivation plays an important role in defending the esophageal mucosa. Nizatidine, a histamine H2 receptor antagonist, inhibits acetylcholine esterase, with a resultant increase in acetylcholine. We experienced a patient with gastroesophageal reflux disease (GERD) and impaired salivary secretion who has been successfully treated with nizatidine.Case report: A 63-year-old female visited our hospital with complaints of heartburn and continuous laryngeal discomfort. Saliva scintigraphy was performed to evaluate the salivary function. Washout ratio was decreased to be 25%¨C40% in individual salivary gland. After the treatment with nizatidine, salivary scintigraphy demonstrated the increased washout ratios. The values of both parotid glands increased up to 90%, whereas those of submandibular glands improved to be around a normal range. GERD symptoms disappeared completely after treatment. In conclusion, nizatidine may be one of therapeutic options for low salivary excretion.
%K Salivary scintigraphy
%K GERD
%K Nizatidine
%K laryngeal discomfort
%U http://la-press.com/article.php?article_id=960