%0 Journal Article
%T Antiplasmodial and larvicidal flavonoids from Derris trifoliate
%A Abiy Yenesew
%A Hannington Twinomuhwezi
%A Jacques M. Kabaru
%A Hoseah M. Akala
%J Bulletin of the Chemical Society of Ethiopia
%D 2009
%I Chemical Society of Ethiopia
%X From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4กไ-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
%K Derris trifoliata
%K Leguminosae
%K Flavanone
%K (S)-Lupinifolin 4กไ-methyl ether
%K Lupinifolin
%K Antiplasmodial
%K Rotenoid
%K Larvicide
%K Aedes aegypti
%U http://www.ajol.info/index.php/bcse/article/view/47665