%0 Journal Article
%T Synthesis and antibacterial activity of some heterocyclic derivatives of sulfanilamide
%A B.B. Subudhi
%A G. Ghosh
%J Bulletin of the Chemical Society of Ethiopia
%D 2012
%I Chemical Society of Ethiopia
%X Considering the promising antimicrobial potential of carbonic anhydrase inhibitors and heterocyclic compounds some heterocyclic derivatives of sulfanilamide (2a-e) were synthesized. The diazotisation of sulfanilamide followed by substitution with ethylacetoacetate and further condensation yielded compounds 2a-c. Schiff base of sulfanilamide with salicylaldehyde on reaction with thioglycollic acid and chloroacetyl chloride resulted in compound 2d-e. The susceptibility of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa to the title compounds (300 ¦Ìg/disc) was investigated and compared to that of nitrofurantoin (300 ¦Ìg/disc) and ciprofloxacin (25 ¦Ìg/disc). The title compounds showed good antimicrobial activity.DOI: http://dx.doi.org/10.4314/bcse.v26i3.15
%K Carbonic anhydrase
%K Sulfanilamide
%K Heterocyclic compounds
%K Antimicrobial activity
%U http://www.ajol.info/index.php/bcse/article/view/80286