%0 Journal Article
%T Synthesis of substituted flavone derivatives as potent antimicrobial agents
%A P. Venkatesan
%A T. Maruthavanan
%J Bulletin of the Chemical Society of Ethiopia
%D 2011
%I Chemical Society of Ethiopia
%X The biological activity of flavone has been enhanced by introducing heteroaryl moiety in C-2 position of chromone derivatives. Thus, 2-(1H-Indol-3-yl)-4H-chromen-4-one derivatives (6a-e) and 2-(2-chloroquinolin-3-yl)-4H-chromen-4-one derivatives (7a-e) were synthesized from corresponding chalcone. They were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents.
%K Chalcone
%K Flavone
%K Chromone
%K Antibacterial activity
%K Antifungal activity
%U http://ajol.info/index.php/bcse/article/view/68594