%0 Journal Article
%T EL SISTEMA RENINA ANGIOTENSINA DESDE LA CIRCULACI¨®N HASTA LA C¨¦LULA: IMPLICACIONES M¨¢S ALL¨¢ DE LA HIPERTENSI¨®N / The renin angiotensin system from circulation to the cell: implications beyond hypertension
%A Yosit Ponce Guti¨¦rrez
%A Arik Ponce Guti¨¦rrez
%J CorSalud
%D 2012
%I Cardiocentro Ernesto Che Guevara
%X ResumenEl sistema renina-angiotensina es m¨¢s complejo de lo que se conoc¨ªa hasta hace poco tiempo, ya que su acci¨®n no solo se circunscribe al plasma sangu¨ªneo, sino que igualmente se ha demostrado su existencia en tejidos como: coraz¨®n, cerebro, ri ¨®n, p¨¢ncreas, aparato reproductor, sistema linf¨¢tico y el tejido adiposo; con acciones activas espec¨ªficas en todos ellos, y al mismo tiempo est¨¢ presente en el interior de diferentes tipos de c¨¦lulas, como cardiomiocitos y fibroblastos. Constituye un sistema endocrino, paracrino y autocrino que es capaz de actuar a sus diferentes niveles de manera independiente o relacionada, y participa no solo en el control de la presi¨®n arterial y homeostasis del agua y sodio como se le atribu¨ªa inicialmente, sino que tambi¨¦n interviene en el correcto funcionamiento de numerosos ¨®rganos, as¨ª como en el mecanismo fisiopatol¨®gico de alteraciones estructurales y funcionales, fundamentalmente cardiovasculares y renales que van mucho m¨¢s all¨¢ de la hipertensi¨®n arterial. / AbstractThe renin-angiotensin system is more complex than was known until recently, since its action is not only limited to the plasma. Its presence has been shown in tissues such as the heart, brain, kidney, pancreas, reproductive system, lymphatic system and adipose tissue, with specific active actions in all of them, and at the same time it is present at the intracellular level of different cell types such as cardiomyocytes and fibroblasts. It is an endocrine, paracrine and autocrine system which is capable of acting at different levels in an independent or related form, taking part not only in the control of blood pressure and homeostasis of water and sodium as initially attributed, but it is also involved in the proper functioning of numerous organs and in the pathophysiological mechanism of structural and functional alterations, mainly cardiovascular and renal, which go far beyond hypertension.
%K Renin-Angiotensin System
%K Cell Physiological Phenomena
%U http://bvs.sld.cu/revistas/cors/pdf/2012/v4n4a12/es/sra.pdf